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Black Pepper | Bioavailability Enhancer


It’s not important how much we ingest, it’s important to know how much we absorb.

Black Pepper is commonly used as spice from time. Black Pepper contains Piperine as chemical constituent. Piperine increases bioavailability ranging from 30%-200%.


Black Pepper for Absorption Enhancing

In Humans P-glycoprotein and cytochrome P450 3A4 (CYP3A4) enzyme is responsible for first pass metabolism and Piperine inhibit the same enzyme. Inhibition of CYP3A4 results in increased absorption also known as bio-enhancement leads to great bioavailability (rate and extent at which drug absorbed in the body).

#PalestraMuscleNutrition’s Pre Workout #PrePalestra contains 5mg Black Pepper extract for better absorption of pre workout drink.




1. Kesarwani, K., Gupta, R., & Mukerjee, A. (2013). Bioavailability enhancers of herbal origin: an overview. Asian Pacific journal of tropical biomedicine, 3(4), 253–266. doi:10.1016/S2221-1691(13)60060-X

2. Han, H.-K. (2011). The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opinion on Drug Metabolism & Toxicology, 7(6), 721–729.doi:10.1517/17425255.2011.570332


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